2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10013
    Codactide
    		Inducer
    Codactide is a synthetic octadecapeptide, with corticotropin-like action.
    Codactide
  • HY-P2336
    CCZ01048
    CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.
    CCZ01048
  • HY-P3489
    β-Corticotropin (swine)
    β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release.
    β-Corticotropin (swine)
  • HY-P4681
    (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)
    (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) is a fragment of the ACTH hormone. (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) can be labeled with I125 on Tyr23 to produce a radiolabeled ligand.
    (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)
  • HY-P1216
    HS014
    		Antagonist
    HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats.
    HS014
  • HY-RS08213
    Mc5r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc5r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc5r Mouse Pre-designed siRNA Set A
    Mc5r Mouse Pre-designed siRNA Set A
  • HY-P1209
    PG106
    		Antagonist
    PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor.
    PG106
  • HY-RS08209
    MC4R Human Pre-designed siRNA Set A
    		Inhibitor

    MC4R Human Pre-designed siRNA Set A contains three designed siRNAs for MC4R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC4R Human Pre-designed siRNA Set A
    MC4R Human Pre-designed siRNA Set A
  • HY-19870A
    Setmelanotide TFA
    		Agonist
    Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.
    Setmelanotide TFA
  • HY-P3978
    ACTH (4-9)
    ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (4-9) is the 4-9 sequence fragment of ACTH.
    ACTH (4-9)
  • HY-RS08205
    Mc2r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc2r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc2r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc2r Rat Pre-designed siRNA Set A
    Mc2r Rat Pre-designed siRNA Set A
  • HY-169731
    RO27-3225 trifluoroacetate
    		Agonist
    RO27-3225 trifluoroacetate is a peptide agonist of melanocortin receptor 4 (MC4R) with neuroprotective and anti-inflammatory activity with an EC50 value of 1 nM, while 8 nM for MC1R. RO27-3225 trifluoroacetate reverses hemorrhagic shock, reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal IL-1β and TNF-α levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation.
    RO27-3225 trifluoroacetate
  • HY-123106
    MCL-0129
    		Antagonist
    MCL-0129 is a compound with anxiolytic and antidepressant activity and is a selective MC4 receptor antagonist that exhibits anxiolytic and antidepressant-like behaviors in multiple rodent models.
    MCL-0129
  • HY-RS08206
    MC3R Human Pre-designed siRNA Set A
    		Inhibitor

    MC3R Human Pre-designed siRNA Set A contains three designed siRNAs for MC3R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC3R Human Pre-designed siRNA Set A
    MC3R Human Pre-designed siRNA Set A
  • HY-129724
    α-MSH(11-13)
    		Control
    α-MSH(11-13) (ACTH-(11-13)) is the 11-13 amino acid (lysine-proline-valine) sequence of α-MSH (HY-P0252), which reduces fever in rabbits.
    α-MSH(11-13)
  • HY-15616
    BMS-470539
    		Agonist
    BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. BMS-470539 selectively activates human and murine MC-1R with EC50 values of 16.8 nM and 11.6 nM, respectively. In vitro studies have shown that BMS-470539 is able to dose-dependently inhibit TNF-alpha-induced NF-kB activation in human melanoma cells expressing MC-1R. In vivo, subcutaneous injection of BMS-470539 into BALB/c mice effectively inhibited LPS-induced TNF-alpha production with an ED50 of approximately 10 μmol/kg and a pharmacodynamic half-life of approximately 8 hours. It also significantly reduced leukocyte infiltration in a lung inflammation model and attenuated paw swelling in a delayed-type hypersensitivity model, highlighting its efficacy as an anti-inflammatory agent through MC-1R modulation.
    BMS-470539
  • HY-RS08202
    MC1R Rat Pre-designed siRNA Set A
    		Inhibitor

    MC1R Rat Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC1R Rat Pre-designed siRNA Set A
    MC1R Rat Pre-designed siRNA Set A
  • HY-134046
    (-)-Isodocarpin
    		Inhibitor
    (-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA.
    (-)-Isodocarpin
  • HY-P1217A
    [D-Trp8]-γ-MSH TFA
    		Agonist
    [D-Trp8]-γ-MSH TFA is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH TFA could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis.
    [D-Trp8]-γ-MSH TFA
  • HY-P10265
    Melanostatin, frog
    		Inhibitor
    Melanostatin, frog is an inhibitor for α-melanocyte-stimulating hormone (α-MSH) release, with an IC50 of 60 nM.
    Melanostatin, frog
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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