2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P3981
    Defensin NP-3A
    		Inhibitor
    Defensin NP-3A (NP-3A; Corticostatin 1) is a human granulocyte peptide, with anti-ACTH activity. Defensins are antimicrobial peptides with and cytotoxic activity.
    Defensin NP-3A
  • HY-P3659
    (D-Phe7)-α-MSH
    (D-Phe7)-α-MSH is an α-MSH analogue.
    (D-Phe7)-α-MSH
  • HY-N0637AR
    (±)-Eriodictyol (Standard)
    3-Chlorobenzoic acid (Standard) is the analytical standard of 3-Chlorobenzoic acid. This product is intended for research and analytical applications. 3-Chlorobenzoic acid (m-Chlorobenzoic acid) is the only carbon source for the bacterium.
    (±)-Eriodictyol (Standard)
  • HY-RS08210
    Mc4r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc4r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc4r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc4r Mouse Pre-designed siRNA Set A
  • HY-P3979
    Defensin HNP 4
    		Inhibitor
    Defensin HNP 4 (HNP 4) is a host-defense peptide that has antimicrobial activity against Gram-negative bacteria. Defensin HNP 4 inhibits ACTH stimulated synthesis of Corticosterone (HY-B1618) in rat adrenal cell suspensions.
    Defensin HNP 4
  • HY-N0998
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one
    		Inhibitor
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 μM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders.
    1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one
  • HY-109114A
    Dersimelagon phosphate
    		Agonist
    Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon phosphate shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon phosphate can be used for the research of skin pigmentation.
    Dersimelagon phosphate
  • HY-RS08200
    MC1R Human Pre-designed siRNA Set A
    		Inhibitor

    MC1R Human Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC1R Human Pre-designed siRNA Set A
  • HY-RS08212
    MC5R Human Pre-designed siRNA Set A
    		Inhibitor

    MC5R Human Pre-designed siRNA Set A contains three designed siRNAs for MC5R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC5R Human Pre-designed siRNA Set A
  • HY-P10013
    Codactide
    		Inducer
    Codactide is a synthetic octadecapeptide, with corticotropin-like action.
    Codactide
  • HY-P2336
    CCZ01048
    CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.
    CCZ01048
  • HY-P3489
    β-Corticotropin (swine)
    β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release.
    β-Corticotropin (swine)
  • HY-P4681
    (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)
    (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) is a fragment of the ACTH hormone. (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) can be labeled with I125 on Tyr23 to produce a radiolabeled ligand.
    (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)
  • HY-P1216
    HS014
    		Antagonist
    HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats.
    HS014
  • HY-RS08213
    Mc5r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc5r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc5r Mouse Pre-designed siRNA Set A
  • HY-P1209
    PG106
    		Antagonist
    PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor.
    PG106
  • HY-RS08209
    MC4R Human Pre-designed siRNA Set A
    		Inhibitor

    MC4R Human Pre-designed siRNA Set A contains three designed siRNAs for MC4R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC4R Human Pre-designed siRNA Set A
  • HY-19870A
    Setmelanotide TFA
    		Agonist
    Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.
    Setmelanotide TFA
  • HY-P3978
    ACTH (4-9)
    ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (4-9) is the 4-9 sequence fragment of ACTH.
    ACTH (4-9)
  • HY-RS08205
    Mc2r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc2r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc2r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc2r Rat Pre-designed siRNA Set A
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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